PAUL J. FOUTS, M.D.; O. M. HELMER, PH.D.; L. G. ZERFAS, M.D., F.A.C.P.
The therapeutic effectiveness of liver and fractions of liver in the treatment of pernicious anemia is well established. Minot, Cohn, Murphy, and Lawson1 demonstrated that although slight reticulocyte responses followed the daily feeding of 60 grams of cooked liver, near-maximal responses did not usually occur unless from 150 to 200 grams of cooked liver were fed. Minot, Murphy, and Stetson2 stated that: "There is apparently some minimal amount of liver in the vicinity of 60 gm. of cooked liver, which is a necessary daily amount to produce a distinct reticulocyte reaction when the red blood cells are about 1.25 million
FOUTS PJ, HELMER OM, ZERFAS LG. QUANTITATIVE STUDIES ON INCREASED POTENCY OF LIVER EXTRACT BY INCUBATION WITH NORMAL HUMAN GASTRIC JUICE1. Ann Intern Med. ;8:790–797. doi: 10.7326/0003-4819-8-7-790
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Published: Ann Intern Med. 1935;8(7):790-797.
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