SAMUEL SOSKIN; LOUIS N. KATZ; ROBERT FRISCH
In a previous communication1 it was shown that the characteristic electrocardiographic changes resulting from insulin hypoglycemia could be obtained in elderly diabetic patients with cardiovascular disease, by the use of therapeutic doses of insulin in amounts which did not cause hypoglycemia. Since similar results could be obtained in these patients by the use of low carbohydrate diets without insulin, and since in both insulin hypoglycemia and in our therapeutic experiments the insulin effects tended to be reversed upon the administration of carbohydrate, it seemed probable that the electrocardiographic distortions were secondary to the effects of the insulin on the available
SOSKIN S, KATZ LN, FRISCH R. THE DUAL NATURE OF THE ACTION OF INSULIN UPON THE HEART1. Ann Intern Med. ;8:900–906. doi: 10.7326/0003-4819-8-8-900
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Published: Ann Intern Med. 1935;8(8):900-906.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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