CECIL M. KOHN, M.D.; SAMUEL A. LEVINE, M.D., F.A.C.P.
Since the introduction of quinidine therapy as a treatment of auricular fibrillation by Frey1 in 1918, enthusiasm for its use has gradually waned. As with many new products in medicine early reports were very favorable, but careful observation over a period of years has shown that the use of the drug in permanent auricular fibrillation is warranted only in exceptional cases. It is indeed questionable whether any form of therapy to restore the normal rhythm is indicated in this condition.
Time has shown that restoration of normal rhythm by quinidine is not apt to be permanent and it becomes evident
KOHN CM, LEVINE SA. AN EVALUATION OF THE USE OF QUINIDINE SULPHATE IN PERSISTENT AURICULAR FIBRILLATION1. Ann Intern Med. ;8:923–938. doi: 10.7326/0003-4819-8-8-923
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Published: Ann Intern Med. 1935;8(8):923-938.
Cardiology, Rhythm Disorders and Devices.
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