C. W. SCULL, Ph.D.; RALPH PEMBERTON, M.D., F.A.C.P.
In 1927 Peirce and Pemberton 15 reported data indicating that, following a stab of the finger, fewer red cells per cubic millimeter are found in the first several drops of blood of patients with severe arthritis, as compared with subsequent drops. While this difference is sometimes discovered in normal persons and in patients with mild arthritis, it is less frequent. Several possible explanations of this phenomenon have been advanced: namely, that the capillaries of normal persons are open in larger numbers; that the first issuing blood in arthritic patients is diluted in the vessels; and, that the normal or decreased
SCULL CW, PEMBERTON R. THE INFLUENCE OF DIETETIC AND OTHER FACTORS ON THE SWELLING OF TISSUES IN ARTHRITIS1: PRELIMINARY REPORT. Ann Intern Med. ;8:1247–1265. doi: 10.7326/0003-4819-8-10-1247
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Published: Ann Intern Med. 1935;8(10):1247-1265.
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