C. N. H. LONG, M.D., D.Sc.
Since the discovery of von Mering and Minkowski some 46 years ago, that total extirpation of the pancreas in animals produced a condition indistinguishable from diabetes mellitus in man, three major problems have confronted both physiologists and clinicians interested in this disease. They are: 1. The isolation and clinical application of the internal secretion of the pancreas. 2. The mode of action of this pancreatic hormone. 3. The elucidation of the mechanisms involved in the production of the diabetic syndrome.
The first problem was solved in 1922 when Banting and Best succeeded in preparing insulin. This discovery was at once
LONG CNH. RECENT ADVANCES IN CARBOHYDRATE METABOLISM WITH PARTICULAR REFERENCE TO DIABETES MELLITUS1. Ann Intern Med. ;9:166–174. doi: 10.7326/0003-4819-9-2-166
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Published: Ann Intern Med. 1935;9(2):166-174.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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