BLANTON P. SEWARD, B.A., M.D., F.A.C.P.
The descriptions of the features of two children in whom no thyroid glands were found at autopsy by Curling1 in 1850, and of sporadic cretinism in England by Fagge2 in 1871, stimulated the interest of physicians in a disease hitherto not investigated. Fagge regarded "wasting of the thyroid body" as the probable cause of cretinism and he predicted with remarkable accuracy some of the symptoms that might result from a deficiency in the secretion of the thyroid in adults. Two years later Sir William Gull3 reported two cases of the cretinoid state developing in adults. In discussing these cases he
SEWARD BP. A CLINICAL STUDY OF THE MILD GRADES OF HYPOTHYROIDISM1. Ann Intern Med. ;9:178–188. doi: 10.7326/0003-4819-9-2-178
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Published: Ann Intern Med. 1935;9(2):178-188.
Endocrine and Metabolism, Thyroid Disorders.
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