CONLEY H. SANFORD, M.D., F.A.C.P.
It appears established, from the experiments of Castle and his co-workers,1, 2, 3 that pernicious anemia is a deficiency disease due to the absence of an intrinsic factor of undetermined nature in the gastric secretion. This intrinsic factor is definitely not hydrochloric acid, though its absence is practically always associated with absence of free hydrochloric acid in the stomach contents. It is well known that this deficiency exerts its influence chiefly on the blood-forming organs and the nervous system. It is a fact, though in my opinion not uniformly appreciated by clinicians and hematologists, that these two systems may be
SANFORD CH. PERNICIOUS ANEMIA WITH NORMAL BLOOD PICTURE1. Ann Intern Med. ;9:189–194. doi: 10.7326/0003-4819-9-2-189
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Published: Ann Intern Med. 1935;9(2):189-194.
Hematology/Oncology, Red Cell Disorders.
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