C. F. MCKHANN; A. A. GREEN; L. E. ECKLES; J. A. V. DAVIES
A number of investigators have found that the umbilical cord blood of infants contains certain antibodies in amounts commensurate with those in the maternal blood stream.1 This would indicate that the immunity of the newborn infant to some of the infectious diseases is derived in part by placental transmission of antibodies from the mother. Protein extracts composed of the globulins derived from the human placenta and the blood contained in it have been prepared and have been demonstrated to contain diphtheria and scarlet fever antitoxins, and antibodies which neutralize poliomyelitis virus and protect exposed, susceptible children against measles.2
MCKHANN CF, GREEN AA, ECKLES LE, DAVIES JAV. IMMUNOLOGICAL APPLICATIONS OF PLACENTAL EXTRACTS; EFFECTIVENESS BY ORAL ADMINISTRATION12. Ann Intern Med. ;9:388–397. doi: 10.7326/0003-4819-9-4-388
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Published: Ann Intern Med. 1935;9(4):388-397.
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