E. COWLES ANDRUS, M.D., F.A.C.P.; DONALD MCEACHERN, M.D.
The metabolic phenomena characteristic of hyperthyroidism are common to both the clinical and the experimental forms. In the clinical disease, these changes may only be observed en masse. They may be measured only as they are reflected in the total displacement of certain equilibria such as the oxygen consumption, carbon dioxide production, glucose tolerance, nitrogen balance, and the creatine metabolism.
Experimental hyperthyroidism may be produced in animals to any desired degree by the administration of thyroid extract or by the injection of thyroxine. Under these circumstances it is possible to analyze the metabolic alterations and to subject various elements thereof
ANDRUS EC, MCEACHERN D. STUDIES ON THE INCREASED METABOLISM IN HYPERTHYROIDISM1. Ann Intern Med. 1935;9:579–585. doi: 10.7326/0003-4819-9-5-579
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Published: Ann Intern Med. 1935;9(5):579-585.
Endocrine and Metabolism, Thyroid Disorders.
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