A. T. MILHORAT; H. G. WOLFF, F.A.C.P.
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1. Patients with diseases which affect the skeletal muscle commonly have a creatinuria even when they are maintained on a creatine-free diet. Accompanying the creatinuria, there is usually a diminution in the excretion of creatinine and in the ability of the body to retain ingested creatine (a low creatine tolerance).
2. In progressive muscular dystrophy, often large amounts of creatine are excreted. The level of the creatinuria and the impairment of the creatine tolerance are usually related to the amount of muscle disability. In advanced stages of the disease the creatine tolerance may be impaired to the extent that all
MILHORAT AT, WOLFF HG. METABOLISM OF CREATINE AND CREATININE IN MUSCLE DISEASE1. Ann Intern Med. ;9:834–837. doi: 10.7326/0003-4819-9-7-834
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Published: Ann Intern Med. 1936;9(7):834-837.
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