LEANDRO M. TOCANTINS
When a moderate dose of antiplatelet serum is given to a dog, the animal develops an attack of purpura hemorrhagica, identical in most respects with the human type, and recovers spontaneously. The changes that accompany such a disease in the dog have not as yet been systematically investigated. The observations here presented are the result of a study of some of these changes in a group of 63 dogs in each one of which purpura was produced one or more times.
Cytology. Various methods of counting platelets1, 2, 3 were tried and the direct method was finally selected.
TOCANTINS LM. EXPERIMENTAL THROMBOPENIC PURPURA; CYTOLOGICAL AND PHYSICAL CHANGES IN THE BLOOD1. Ann Intern Med. ;9:838–849. doi: 10.7326/0003-4819-9-7-838
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Published: Ann Intern Med. 1936;9(7):838-849.
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