TRACY J. PUTNAM, M.D.
In previous communications, it has been pointed out that lesions closely resembling typical plaques of multiple sclerosis may be produced in animals in either of two ways: by the subcutaneous injection of minute doses of tetanus toxin1 and by experimental obstruction of cerebral venules.2 In each case sclerotic lesions could be demonstrated only after an interval of several months from the original injury. The earlier lesions closely resembled those of "post-infectious encephalomyelitis," a disease occasionally seen following measles3 and vaccinia4 and often without obvious antecedent. Areas of demyelination, with relative persistence of
TRACY J. PUTNAM. STUDIES IN MULTIPLE SCLEROSIS: VIII. ETIOLOGIC FACTORS IN MULTIPLE SCLEROSIS(VIII. ETIOLOGIC FACTORS IN MULTIPLE SCLEROSIS*). Ann Intern Med. 1936;9:854–863. doi: 10.7326/0003-4819-9-7-854
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Published: Ann Intern Med. 1936;9(7):854-863.
Multiple Sclerosis, Neurology.
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