HENRY A. RAFSKY, F.A.C.P.; ADOLPH BERNHARD; GEORGE L. ROHDENBURG
In a previous publication1 we reported that experimental hypertension in rabbits produced by the injection of a mono-amino acid (aspartic acid) is associated with definite alterations in the nitrogen distribution of the serum proteins. These changes are an increase in the mono-amino nitrogen and a decrease in the basic amino nitrogen with a resultant change in the ratio between these two fractions (referred to as the M/B ratio). We have noted in further studies similar changes in the nitrogen distribution of the serum proteins in hypertension in man. Since these changes offer a basis for the classification of hypertension, the
RAFSKY HA, BERNHARD A, ROHDENBURG GL. STUDIES IN HYPERTENSION; A PROPOSED CLASSIFICATION OF HYPERTENSION BASED UPON THE NITROGEN DISTRIBUTION OF THE SERUM PROTEINS1. Ann Intern Med. ;9:1091–1100. doi: 10.7326/0003-4819-9-8-1091
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Published: Ann Intern Med. 1936;9(8):1091-1100.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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