EDWARD C. REIFENSTEIN, M.D., F.A.C.P.; EDWARD C. REIFENSTEIN JR., M.D.
The treatment of Addison's disease has undergone a marked change in the last five years. Ever since 1855, when Addison first described the insufficiency disease of the suprarenal cortex that now bears his name, investigators have been trying to devise an adequate treatment for this condition.
Previous to 1930, physicians relied chiefly on the Muirhead régime,1 which consisted of administering epinephrine by mouth, by rectum, and subcutaneously at frequent intervals and up to the patient's tolerance, together with "desiccated cortex" by mouth, 10 to 15 grains daily. Results from this regimen were observed in 10 to 20 per
REIFENSTEIN EC, REIFENSTEIN EC. THE TREATMENT OF ADDISON'S DISEASE WITH SODIUM COMPOUNDS, WITH THE REPORT OF ONE CASE AND THE SUMMARIES OF ELEVEN OTHER COLLECTED CASES THUS TREATED1. Ann Intern Med. ;9:1338–1364. doi: 10.7326/0003-4819-9-10-1338
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Published: Ann Intern Med. 1936;9(10):1338-1364.
Adrenal Disorders, Endocrine and Metabolism.
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