SAMUEL S. ALTSHULER, M.D., F.A.C.P.; S. E. GOULD, M.D.
In reviewing the literature on this subject one is struck by the fact that many cases are spoken of as "insulin refractory" which might better be termed "insulin resistant," that is, cases in which an unusually large amount of insulin must be administered in order to control the glycosuria. The case which we are reporting is truly insulin refractory; no relationship is demonstrable between the amounts of insulin given and the subsequent glycosuria.
In most instances the physiological responses to insulin are predictable, but the mechanism of its action is still problematical. The proper understanding of this mechanism is reserved
ALTSHULER SS, GOULD SE. DIABETES REFRACTORY TO INSULIN, WITH REPORT OF A CASE1. Ann Intern Med. 1936;9:1595–1603. doi: 10.7326/0003-4819-9-11-1595
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Published: Ann Intern Med. 1936;9(11):1595-1603.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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