From the nosological aspect generalized amyloidosis has not received its due recognition. It has hitherto been largely viewed as an ominous sequel of chronic suppuration, with cachexia, anemia, swelling of the liver and spleen, and albuminuria as the most prominent clinical expressions. In recent years, new data have been established which have widened the diagnostic basis of this disease. These are the recognition: (1) of primary amyloidosis; (2) of so-called atypical amyloidosis; (3) of the relation of general amyloidosis to "nephrotic," or better termed, hypoproteinemic states; and (4) the establishment of the Bennhold Congo red test. These viewpoints and
MOSCHCOWITZ E. THE CLINICAL ASPECTS OF AMYLOIDOSIS1. Ann Intern Med. ;10:73–88. doi: 10.7326/0003-4819-10-1-73
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Published: Ann Intern Med. 1936;10(1):73-88.
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