DOUGLAS BOYD, M.D.; STAFFORD L. OSBORNE, B.P.E.; DAVID E. MARKSON, M.D., F.A.C.P.
Many investigators have studied the value of choline compounds in the treatment of conditions involving vascular spasm. Acetylcholine has long been known but, because of its nicotine-like action, is not suitable for therapeutic use. Major and Kline1 synthesized acetyl beta methylcholine chloride, a more stable compound, free from the nicotine-like side effects of previous compounds. When Starr2 compared the action of acetyl beta methylcholine with acetylcholine, he found they had similar effects on the cardio-vascular system of animals when given intravenously. He also found acetyl beta methylcholine chloride more than 10 times as active as acetylcholine when given hypodermically in
BOYD D, OSBORNE SL, MARKSON DE. OBSERVATIONS ON THE USE OF ACETYL BETA METHYLCHOLINE CHLORIDE IN CHRONIC ARTHRITIS1. Ann Intern Med. ;10:728–741. doi: 10.7326/0003-4819-10-6-728
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Published: Ann Intern Med. 1936;10(6):728-741.
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