HAROLD R. ROEHM, M.D., F.A.C.P.; AARON RIKER, A.B., M.D.; RICHARD E. OLSEN, Sc.D., M.D.
Chloroma is not a common form of malignant tumor. Washburn1 in a review of the literature through June 1929 found 162 cases. Since that time 32 more have been reported, bringing the total to 194.
Dock and Warthin2 in 1904 published an exhaustive study of the clinical and histological features of the disease. Their conclusion was that, "chloroma is a tumor-like hyperplasia of the parent cells of the leukocytes, primarily in red marrow, the periosteum being secondarily involved."
In the past, opinions have been divided concerning the lymphatic or myelogenous origin of the neoplasm, but the general opinion at present
ROEHM HR, RIKER A, OLSEN RE. CHLOROMA; REPORT OF A CASE1. Ann Intern Med. ;10:1054–1061. doi: 10.7326/0003-4819-10-7-1054
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Published: Ann Intern Med. 1937;10(7):1054-1061.
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