HERMAN BOLKER, M.D.; MENDEL JACOBI, M.D.; MORRIS T. KOVEN, M.D.
Proved cases of primary carcinoma of the liver are few in number, particularly so in comparison with the frequent occurrence of secondary neoplasms of that organ, which are found in about 2.5 per cent of autopsies. Distant metastases of new-growths primary in the liver are potentially common because of the characteristic tendency of the cells to invade the walls and lumina of the venous radicals. Of these metastases, one of the most unusual is that to the skeletal system, a search of the literature revealing only the following nine instances.
Schmidt,1 in a man of 55, found a primary tumor
BOLKER H, JACOBI M, KOVEN MT. PRIMARY CARCINOMA OF THE LIVER WITH BONE METASTASIS1. Ann Intern Med. ;10:1212–1221. doi: 10.7326/0003-4819-10-8-1212
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Published: Ann Intern Med. 1937;10(8):1212-1221.
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