HARRY SHAY, M.D.; PHILIP FIEMAN, M.D.
In 1931, in a paper on the study of the metabolism of galactose in the human subject, Shay, Schloss and Bell1 concluded that this hexose was best suited for testing the carbohydrate function of the liver. In order for the urinary excretion of this sugar, orally administered, to act as a measure of hepatic carbohydrate function, they considered the following among the necessary conditions: (1) that there be no renal threshold for the excretion of galactose; (2) that galactose utilization remain unmodified by the activity of those endocrine glands known to affect glucose metabolism; (3) that galactose be practically unutilizable
SHAY H, FIEMAN P. THE GALACTOSE TOLERANCE TEST IN JAUNDICE; A CONSIDERATION OF THE EVIDENCE PERMITTING THE MEASUREMENT OF GALACTOSE UTILIZATION BY URINARY EXCRETION; SOME SOURCES FOR ERROR IN ITS INTERPRETATION; AND AN ADDITION IN ROUTINE TECHNIC1. Ann Intern Med. ;10:1297–1303. doi: 10.7326/0003-4819-10-9-1297
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Published: Ann Intern Med. 1937;10(9):1297-1303.
Gastroenterology/Hepatology, Hospital Medicine.
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