ELLIS W. WILLHELMY, M.D.
In 1923, Mann and Williamson1 reported that they were able to produce in dogs subacute and chronic peptic ulcers, quite like those found in man, by diverting to another part of the intestine those secretions of the duodenum which normally neutralize the gastric juice as it leaves the stomach.
Aron and Weiss2 of Strasbourg repeated and confirmed these studies. They came to the conclusion that these ulcers formed as a result of an amino acid deficiency. On this theory, they gave intramuscular injections of certain amino acids to dogs that had been subjected to the Mann-Williamson technic, and found that
WILLHELMY EW. FURTHER OBSERVATIONS OF THE HISTIDINE TREATMENT OF PEPTIC ULCER1. Ann Intern Med. ;10:1365–1370. doi: 10.7326/0003-4819-10-9-1365
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Published: Ann Intern Med. 1937;10(9):1365-1370.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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