G. L. WALDBOTT, M.D., F.A.C.P.; M. S. ASCHER, M.D.
Recent textbooks on allergy make only little mention of rapid hyposensitization 2 treatment and only a few clinicians have given this method serious consideration. The method of administering small increasing doses of antigen at short intervals was first introduced by Besredka1 for the avoidance of serum reactions after he had observed that in animals the re-injection of a sublethal dose of antigen resulted in a temporary state of anti-anaphylaxis and that during this state larger doses of antigen could be more readily tolerated.
In 1930 Freeman2 adopted this method of treatment for the relief of patients with hay-fever and asthma.
WALDBOTT GL, ASCHER MS. FURTHER OBSERVATIONS ON RAPID HYPOSENSITIZATION1. Ann Intern Med. ;10:1556–1564. doi: 10.7326/0003-4819-10-10-1556
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Published: Ann Intern Med. 1937;10(10):1556-1564.
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