WILLIAM E. EHRICH, M.D.; E. B. KRUMBHAAR, M.D., Ph.D., F.A.C.P.
Of the synthetic preparations of the epinephrine group, benzedrine (phenylisopropylamine) is in some respects more efficient than epinephrine and ephedrine, and also has additional therapeutic effects. As a sympathetic stimulant it produces mydriasis and piloerection (Alles1; Prinzmetal and Bloomberg2; Myerson, Loman and Dameshek3). It raises both blood and spinal fluid pressure, the rise being maintained for a longer period than after injection of the other two drugs (Alles1; Piness, Miller and Alles4; Hartung and Munch5; Tainter6; Myerson, Loman and Dameshek3). Like these drugs, it increases the number of erythrocytes and leukocytes in the blood, and to a lesser extent the
EHRICH WE, KRUMBHAAR EB. AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT: THE EFFECTS OF LARGE DOSES OF BENZEDRINE SULPHATE ON THE ALBINO RAT: FUNCTIONAL AND TISSUE CHANGES(THE EFFECTS OF LARGE DOSES OF BENZEDRINE SULPHATE ON THE ALBINO RAT: FUNCTIONAL AND TISSUE CHANGES*). Ann Intern Med. 1937;10:1874–1888. doi: 10.7326/0003-4819-10-12-1874
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Published: Ann Intern Med. 1937;10(12):1874-1888.
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