P. A. GRAY, M.D., F.A.C.P.; FRITZ BISCHOFF, PH.D.; W. D. SANSUM, M.D., F.A.C.P.
Throughout the past two years we have been studying the effect of insoluble insulin compounds in the treatment of human diabetes mellitus. The clinical results obtained with insulin tannate and insulin-zinc compounds have already been reported.1 This communication deals with our clinical trial of the histone-insulin compound discovered and prepared for clinical use by one of us (F. B.2). This preparation has been found capable of controlling diabetes when used alone. Because of its slow and prolonged action on the blood sugar it is particularly useful in severe types of diabetes in juvenile patients and in elderly cases with cardiovascular
GRAY PA, BISCHOFF F, SANSUM WD. TREATMENT OF DIABETES MELLITUS WITH INSOLUBLE INSULIN COMPOUNDS: II. HISTONE-INSULIN1. Ann Intern Med. ;11:274–284. doi: 10.7326/0003-4819-11-2-274
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Published: Ann Intern Med. 1937;11(2):274-284.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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