MICHAEL J. LEPORE
During the past decade evidence has accumulated from many quarters lending support to the physico-chemical concept of edema formation advanced originally by Starling1 in 1895. The basis of this theory is that capillary pressure and serum colloid osmotic pressure are opposing forces, the balance between which determines the direction of movement of fluid and of the crystalloidal constituents of the blood across the capillary wall. In view of the numerous excellent papers on the subject, it is needless to review the evidence establishing the validity of the Starling concept in explaining the mechanism of production of nephrotic edema. The lowering
LEPORE MJ. ACACIA THERAPY IN NEPHROTIC EDEMA1. Ann Intern Med. ;11:285–296. doi: 10.7326/0003-4819-11-2-285
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Published: Ann Intern Med. 1937;11(2):285-296.
Nephrology, Nephrotic Syndrome.
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