WILLIAM G. LENNOX, M.D.; HILDEGARDE C. LEONHARDT
In about 90 per cent of patients suffering from an attack of migraine headache, the injection of ergotamine tartrate causes complete disappearance of the pain and other symptoms.1 In the case of the more recently isolated alkaloid of ergot, ergonovine, clinical results are not so striking. In our 54 patients who received injection of the drug, pain was stopped in 39 per cent and was improved in a further 40 per cent.2 The beneficial action of ergot seems to be specific for headaches of the migraine type.3 These welcome therapeutic results led us to investigate the physiological effects of these
LENNOX WG, LEONHARDT HC. AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT: THE FLOW AND CONCENTRATION OF BLOOD AS INFLUENCED BY ERGOT ALKALOIDS AND AS INFLUENCING MIGRAINE1. Ann Intern Med. ;11:663–670. doi: 10.7326/0003-4819-11-4-663
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Published: Ann Intern Med. 1937;11(4):663-670.
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