ARTHUR C. KERKHOF, B.S., Ph.D., M.D.
Numerous investigators have produced edema by a reduction of the plasma proteins. The reduction of the plasma proteins by repeated bleedings is called plasmapheresis. Leiter1,2 and Barker and Kirk3 were the first to carry on this work. Since that time numerous investigators, chiefly Shelburne and Egloff,4 Lepore,5 Darrow, Hopper and Carey,6 Weech, Snelling and Goettsch,7 Kylin8 and ourselves9,10 have carried on these experiments. Our method of plasmapheresis has been essentially the following: Five to eight hundred cubic centimeters of normal blood were obtained from the right or left ventricle of a normal dog. This blood was citrated, centrifuged, the plasma
KERKHOF AC. PLASMAPHERESIS EXPERIMENTS UPON THE INFLUENCE OF COLLOID OSMOTIC PRESSURE, WATER AND SALT IN EDEMA FORMATION1. Ann Intern Med. 1938;11:1407–1415. doi: 10.7326/0003-4819-11-8-1407
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Published: Ann Intern Med. 1938;11(8):1407-1415.
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