HENRY JOACHIM, M.D., F.A.C.P.; MORRIS M. BANOWITCH, M.D., F. A. C. P.
The syndrome of spontaneous hypoglycemia described by Seale Harris1 was attributed by him to hyperinsulinism. Since then this conception has been amply confirmed by numerous reports in the literature, and particularly demonstrated by Wilder, Allan, Power and Robertson2 in 1927. They reported a case of carcinoma of the islands of Langerhans with liver and lymph node metastases, the extract of which was found capable of lowering the blood sugar in rabbits.
In the past 10 years numerous cases of spontaneous hypoglycemia due to tumor formation have been reported but the great majority have been due to hyperfunctioning of adenomas of
JOACHIM H, BANOWITCH MM. A CASE OF CARCINOMA OF THE ISLANDS OF LANGERHANS WITH HYPOGLYCEMIA1. Ann Intern Med. 1938;11:1754–1759. doi: 10.7326/0003-4819-11-9-1754
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Published: Ann Intern Med. 1938;11(9):1754-1759.
Gastroenterology/Hepatology, Hematology/Oncology, Pancreatic Disease.
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