HOWARD A. RUSK, M.D., F.A.C.P.; BRUCE D. KENAMORE, M.D.
Urticaria is a localized and circumscribed edema of the skin due to contraction and distorted osmotic balance in the superficial capillaries of the cutis. It has long been considered to be an allergic manifestation, but anyone who has dealt with chronic urticaria has encountered the refractive cases which in spite of all types of allergic withdrawals and desensitizations, will respond to no therapeutic measure. A number of cases are reported in the literature that have continued for many years without relief. Evaluating the allergic factor in the problem is unusually difficult, as this type of case gives the poorest response
RUSK HA, KENAMORE BD. URTICARIA—A NEW THERAPEUTIC APPROACH1. Ann Intern Med. ;11:1838–1844. doi: 10.7326/0003-4819-11-10-1838
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Published: Ann Intern Med. 1938;11(10):1838-1844.
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