HAROLD JEGHERS, M.D.; HENRY J. BAKST, M.D.
Azotemia signifies an abnormal increase in the non-protein nitrogen (NPN) level of the blood. Normally the blood of a fasting person contains from 25 to 35 mg. per cent of non-protein nitrogen; this includes urea, uric acid, ammonia, amino acid, creatine, creatinine and some nitrogenous substances known as undetermined nitrogen or rest nitrogen. Values for blood non-protein nitrogen over 40 mg. per 100 c.c. are considered abnormal.
Theoretically an azotemia could be caused by an increase of any of these non-protein nitrogen constituents. The amounts of uric acid, ammonia, creatine and creatinine are so small that increases of even several
JEGHERS H, BAKST HJ. THE SYNDROME OF EXTRARENAL AZOTEMIA1. Ann Intern Med. ;11:1861–1899. doi: 10.7326/0003-4819-11-10-1861
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Published: Ann Intern Med. 1938;11(10):1861-1899.
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