Two reasons prompted us to administer bile to patients with peptic ulcer: the evidence from experiments with animals that ulceration of the stomach or duodenum may follow the diversion of bile from the duodenum, and certain other evidence which suggests that the disease may result from some type of deficiency.
Numerous studies have been reported in which ulceration has developed after interference with the normal secretions in the duodenum. A review of the literature on this subject has been published by us in two previous articles1, 2 and will not be repeated here. Briefly, the various experimental methods that have
PEPTIC ULCER: THE EFFECT OF THE ADMINISTRATION OF BILE ON THE BEHAVIOR OF THE DISEASE1. Ann Intern Med. 1938;11:2007–2017. doi: 10.1059/0003-4819-11-11-2007
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Published: Ann Intern Med. 1938;11(11):2007-2017.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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