ALEXANDER B. GUTMAN; W. BARCLAY PARSONS
Generalized osteitis fibrosa cystica (von Recklinghausen's disease) and osteitis deformans (Paget's disease) were regarded formerly as related variants of a single skeletal disease. This concept, however, proved irreconcilable with subsequent clinical, roentgenologic, biochemical and pathologic observations and the consensus now is that generalized osteitis fibrosa cystica and osteitis deformans are discrete and unrelated entities.1 Generalized osteitis fibrosa cystica has been shown to be due to hyperparathyroidism2 whereas osteitis deformans is not due to hyperparathyroidism but to unknown, probably local, factors influencing bone metabolism.
A serious difficulty with the prevailing view, however, lies in the increasing number of patients described as
GUTMAN AB, PARSONS WB. HYPERPARATHYROIDISM SIMULATING OR ASSOCIATED WITH PAGET'S DISEASE; WITH THREE ILLUSTRATIVE CASES1. Ann Intern Med. ;12:13–31. doi: 10.7326/0003-4819-12-1-13
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Published: Ann Intern Med. 1938;12(1):13-31.
Endocrine and Metabolism, Parathyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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