HORACE MARSHALL KORNS, M.D.; WILLIAM LLOYD RANDALL, M.D.
In January, 1937, in a report1 of our experience with benzedrine in the treatment of orthostatic hypotension, we pointed out that if amounts of either benzedrine or ephedrine sufficiently large to maintain the blood pressure within normal limits were employed for more than a few days at a time, it became difficult, even with full doses of the various barbiturates, to overcome the consequent insomnia. When this statement caught the eye of Mr. W. F. Thompson, of the Smith, Kline and French Laboratories, he suggested that we try paredrine (beta-parahydroxyphenylisopropylamine), a related amine, which, according to preliminary pharmacologic studies,2, 3,
KORNS HM, RANDALL WL. BENZEDRINE AND PAREDRINE IN THE TREATMENT OF ORTHOSTATIC HYPOTENSION, WITH SUPPLEMENTARY CASE REPORT1. Ann Intern Med. 1938;12:253–255. doi: 10.7326/0003-4819-12-2-253
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Published: Ann Intern Med. 1938;12(2):253-255.
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