DAVID MARINE, M.D., F.A.C.P.
The chronic progressive exophthalmos of the type seen in Graves' disease, even when uncomplicated, is obviously a highly complex phenomenon, perhaps as complex etiologically as Graves' disease. Although both have been studied for more than a century they are still involved in doubt and controversy.
My primary interest in the study of exophthalmos has been the hope that a further understanding of this symptom might throw additional light on the etiology of Graves' disease. There is also the immediately practical question of how to continue subtotal thyroidectomy in the treatment of Graves' disease and at the same time prevent the
MARINE D. STUDIES ON THE PATHOLOGICAL PHYSIOLOGY OF THE EXOPHTHALMOS OF GRAVES' DISEASE1. Ann Intern Med. ;12:443–453. doi: 10.7326/0003-4819-12-4-443
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Published: Ann Intern Med. 1938;12(4):443-453.
Endocrine and Metabolism, Thyroid Disorders.
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