MAURICE HARDGROVE, M.D.; GRACE M. ROTH, PH.D.; GEORGE E. BROWN, M.D., F.A.C.P.
The specific stimulating action of carbon dioxide on the vasomotor centers and its pressor effect on blood pressure have been known for some time. As early as 1864, Thiry1 observed a rise of the blood pressure of animals during the inhalation of carbon dioxide and expressed the opinion that this was the result of stimulation of the vasomotor center, which produces a constriction of the peripheral arterioles. Traube2 later confirmed this work and also looked on carbon dioxide as an excitant of the vasomotor center. In contrast to this work, Gaskell3 about the same time demonstrated by perfusion experiments that
HARDGROVE M, ROTH GM, BROWN GE. THE PRESSOR REACTION PRODUCED BY INHALATION OF CARBON DIOXIDE; STUDIES OF PATIENTS WITH NORMAL BLOOD PRESSURE AND WITH HYPERTENSION1. Ann Intern Med. ;12:482–492. doi: 10.7326/0003-4819-12-4-482
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Published: Ann Intern Med. 1938;12(4):482-492.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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