GRAFTON TYLER BROWN, B.S., M.D., F.A.C.P.
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Although much has been written about local and focal reactions, little or no attention has been paid to constitutional reactions from bacterial vaccine injections. These systemic bacterial reactions are entirely different from the constitutional reactions sometimes encountered following treatments with food, animal epidermal, pollen, or other kinds of protein extracts. An overdose of vaccine will frequently cause an aggravation of the patient's trouble, but the type of constitutional reaction that I am about to describe is a definite shock reaction, comparable to that produced by the intentional intravenous injection of a small dose of typhoid vaccine in foreign protein therapy.
BROWN GT. CONSTITUTIONAL REACTIONS FROM BACTERIAL VACCINES1. Ann Intern Med. 1938;12:493–494. doi: 10.7326/0003-4819-12-4-493
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Published: Ann Intern Med. 1938;12(4):493-494.
Infectious Disease, Prevention/Screening, Vaccines/Immunization.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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