FRED E. ANGLE, M.D.; WILLIAM H. ALGIE, M.D.; LEONA BAUMGARTNER, M.D., PH.D.; W. F. LUNSFORD, M.D.
In human beings cutaneous hypersensitivity to organisms of the genus Brucella was first investigated by Fleischner and Meyer1 in 1918. Using a saline suspension of organisms they tested 75 infants who had been fed milk containing B. abortus and found two with a specific skin sensitivity. Burnet,2 subsequently, used a broth filtrate and demonstrated a relationship between skin reactivity and the presence of specific agglutinins in the blood stream. Since then the test has been used frequently for the diagnosis of undulant fever3, 4, 5, 6, 7, 8, 9, 10, 11 also in surveys designed to evaluate the incidence of
ANGLE FE, ALGIE WH, BAUMGARTNER L, LUNSFORD WF. SKIN TESTING FOR BRUCELLOSIS (UNDULANT FEVER) IN SCHOOL CHILDREN1. Ann Intern Med. ;12:495–502. doi: 10.7326/0003-4819-12-4-495
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Published: Ann Intern Med. 1938;12(4):495-502.
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