FRED M. SMITH, M.D., F.A.C.P.; W. D. PAUL, M.D.
Cases of bronchial asthma are not infrequently encountered in which it is extremely difficult or perhaps even impossible to rule out a cardiac factor. Chronic bronchial asthma is invariably associated with varying degrees of emphysema. The latter results in permanent reduction of the vital capacity which, in some, may reach a low level. With a significant reduction of the vital capacity, shortness of breath appears on exertion, the venous pressure may be increased and occasionally dependent edema is observed. Moreover, the asthmatic attacks commonly occur more frequently and are often precipitated by exercise. Finally, it is generally agreed that the
SMITH FM, PAUL WD. CONCERNING THE DIFFERENTIATION BETWEEN BRONCHIAL ASTHMA VS. CARDIAC DISEASE, AND POSSIBLE ILL EFFECTS FROM THE ADMINISTRATION OF EXCESSIVE AMOUNTS OF EPINEPHRINE IN THE FORMER CONDITION1. Ann Intern Med. 1938;12:585–591. doi: 10.7326/0003-4819-12-5-585
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Published: Ann Intern Med. 1938;12(5):585-591.
Asthma, Cardiology, Pulmonary/Critical Care.
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