J. H. MEANS, M.D., F.A.C.P.; J. LERMAN, M.D.
In 1924 Segall and Means1 published a curve which represented the average of the basal metabolic responses of a series of thyrotoxic patients to subtotal thyroidectomy, without the previous administration of iodine. They called this the detoxication curve. About a year later Starr, Segall and Means2 published a curve similarly obtained and constructed, representing the basal metabolic response of a similar series of thyrotoxic patients to the oral administration of iodine.2
The impressive feature of these two curves was that, save for a post-operative hump on the thyroidectomy curve, the two were, in shape and rate of descent, close to
MEANS JH, LERMAN J. THE CURVES OF THYROXINE DECAY IN MYXEDEMA AND OF IODINE RESPONSE IN THYROTOXICOSIS: THEIR SIMILARITY AND ITS POSSIBLE SIGNIFICANCE1. Ann Intern Med. ;12:811–820. doi: 10.7326/0003-4819-12-6-811
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Published: Ann Intern Med. 1938;12(6):811-820.
Endocrine and Metabolism, Thyroid Disorders.
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