KENDALL A. ELSOM, M.D.; PAUL M. GLENN, M.D.
The recent experiments of Goldblatt and his collaborators have shown that hypertension follows the production of renal ischemia in the dog. The facts that its development is entirely independent of the renal1 or sympathetic nerves2 and that its maintenance depends on the presence in the body of ischemic renal tissue3 suggest that the hypertension so produced is due to a circulating pressor substance. This view is strengthened by the demonstration that kidneys of animals rendered hypertensive by experimental renal ischemia yield on extraction pressor substances in greater amount than do normal kidneys.4, 5 These observations have stimulated the search both
ELSOM KA, GLENN PM. THE PRESSOR RESPONSE OF NORMAL AND HYPERTENSIVE HUMAN SUBJECTS TO TYRAMINE INTRODUCED INTO THE ILEUM1. Ann Intern Med. ;12:838–844. doi: 10.7326/0003-4819-12-6-838
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Published: Ann Intern Med. 1938;12(6):838-844.
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