MORRIS FLEXNER, M.D., F.A.C.P.; BERNARD SCHNEIDER, M.D., D.N.B.
Epinephrine is regarded as a harmless drug, the only common contraindications being angina pectoris and hypertension. Its use in the field of allergy is practically universal. Serious complications following its subcutaneous administration are not reported. Hence, we feel that the occurrence of a subarachnoid hemorrhage following the subcutaneous injection of 0.5 c.c. of epinephrine 1/1000 solution is of sufficient interest to be reported in detail.
The recognition of subarachnoid hemorrhage as a clinical entity has been greatly simplified since the report of Symonds and Cushing1 in 1923, dealing with intracranial aneurysm. Previous to this, the reports were largely
FLEXNER M, SCHNEIDER B. SUBARACHNOID HEMORRHAGE FOLLOWING INJECTION OF EPINEPHRINE1. Ann Intern Med. ;12:876–882. doi: 10.7326/0003-4819-12-6-876
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Published: Ann Intern Med. 1938;12(6):876-882.
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