R. F. IVES, M.D., F.A.C.P.
The fundamental discovery by Domagk1-4 of the protective action of certain sulphonamide derivatives of the azo dyes in experimental hemolytic streptococcic infection, and the supplementary demonstration by Tréfouel, Tréfouel, Nitti, and Bovet5 of the similar action of para-aminobenzenesulphonamide, have received abundant confirmation.6-13 From the date of Domagk's original publication1 an ever increasing volume of clinical reports has been appearing in the current medical periodicals concerning the favorable influence of these chemotherapeutic agents in the treatment of the various types of hemolytic streptococcic infection. This literature has contained scattered references to the therapeutic results obtained in the treatment of acute pharyngitis,
IVES RF. HEMOLYTIC STREPTOCOCCIC ANGINA WITH AGRANULOCYTOSIS TREATED WITH PRONTOSIL AND SULPHANILAMIDE1. Ann Intern Med. ;12:882–887. doi: 10.7326/0003-4819-12-6-882
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Published: Ann Intern Med. 1938;12(6):882-887.
Cardiology, Coronary Heart Disease.
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