ROBERT W. WILKINS, M.D.; SOMA WEISS, M.D., F.A.C.P.; F. H. L. TAYLOR, Ph.D.
Pyruvic acid has long been known as an intermediary product of carbohydrate metabolism. Nevertheless, there are but few reports on the pharmacological action of this substance in higher animals1, 2 and, so far as we know, none on its action in human beings. Recently, considerable importance has been attached to pyruvic acid, chiefly through the rôle claimed for it in vitamin B1 deficiencies. Peters and his coworkers3 consider it an important, if not a specific substance in the "biochemical lesion" in experimental B1 deficiency states, while Platt and Lu4 report increased amounts of pyruvic acid in the blood, spinal fluid
WILKINS RW, WEISS S, TAYLOR FHL. THE EFFECT AND RATE OF REMOVAL OF PYRUVIC ACID ADMINISTERED TO NORMAL PERSONS AND TO PATIENTS WITH AND WITHOUT "VITAMIN B DEFICIENCY"1. Ann Intern Med. ;12:938–950. doi: 10.7326/0003-4819-12-7-938
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Published: Ann Intern Med. 1939;12(7):938-950.
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