JULIUS LOMAN, M.D.; MARK FALCON LESSES, M.D.; ABRAHAM MYERSON, M.D.
In previous experiments1, 2 on the pharmacology of the autonomic nervous system, it was found that the blood pressure elevation produced by benzedrine sulfate (benzylmethyl carbinamine or beta-phenyl-isopropylamine) was quickly lowered by an injection of mecholyl (acetyl-beta-methylcholine chloride). This effect was of short duration, the blood pressure quickly resuming the high level produced by the benzedrine.
In the present study, our aim was to compare the blood pressure lowering effect of mecholyl iontophoresis on benzedrine-induced hypertension and on senile hypertension.
The technic of mecholyl iontophoresis has been described by many authors, including ourselves.3, 4, 5, 6, 7 The drug is
LOMAN J, LESSES MF, MYERSON A. HUMAN AUTONOMIC PHARMACOLOGY: XV. THE EFFECT OF ACETYL-BETA-METHYLCHOLINE CHLORIDE (MECHOLYL) BY IONTOPHORESIS ON ARTERIAL HYPERTENSION(XV. THE EFFECT OF ACETYL-BETA-METHYLCHOLINE CHLORIDE (MECHOLYL) BY IONTOPHORESIS ON ARTERIAL HYPERTENSION*). Ann Intern Med. 1939;12:1213–1222. doi: 10.7326/0003-4819-12-8-1213
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Published: Ann Intern Med. 1939;12(8):1213-1222.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology, Neurology.
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