FREDERICK M. ALLEN
When insufficient carbohydrate is eaten to protect against insulin, there is naturally a recourse to forced administration of glucose either by stomach or parenterally. In dealing with large doses it is necessary to take account of the toxicity of glucose, though there seems to be no positive information as to whether the injury is entirely physical (osmotic) or whether there is an additional chemical action.
The writer (1913) published the first experiments with prolonged administration of various sugars by various channels, with a view to the diabetogenic influence and also other possible effects of chronic hyperglycemia. Regarding the
ALLEN FM. TOLERANCE AND TOXICITY OF INSULIN: II. WITH FORCED ADMINISTRATION OF CARBOHYDRATE(II. WITH FORCED ADMINISTRATION OF CARBOHYDRATE*). Ann Intern Med. 1939;12:1263–1278. doi: 10.7326/0003-4819-12-8-1263
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Published: Ann Intern Med. 1939;12(8):1263-1278.
Cardiology, Coronary Risk Factors, Diabetes, Emergency Medicine, Endocrine and Metabolism.
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