MYRON PRINZMETAL; BEN FRIEDMAN; DAVID I. ABRAMSON, F.A.C.P.
Since cardiac output,1 blood volume,2 and blood viscosity3 are normal in patients with hypertension, the only remaining factor that might produce the elevated blood pressure is an increased peripheral resistance. This increased resistance is presumably generalized throughout the systemic circulation, and is the result of vascular hypertonus4 confined to the arterioles although the small arteries may also be involved.5
The generalized arteriolar hypertonus responsible for hypertension could theoretically be produced by increased sympathetic vasomotor impulses or by circulating substances having a direct or indirect constrictor action on the arterioles.
Hypertension may be produced experimentally by means of renal ischemia,7 ureteral
PRINZMETAL M, FRIEDMAN B, ABRAMSON DI. THE NATURE OF ARTERIAL HYPERTENSION WITH SPECIAL REFERENCE TO THE RÔLE OF THE KIDNEY1. Ann Intern Med. ;12:1604–1616. doi: 10.7326/0003-4819-12-10-1604
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Published: Ann Intern Med. 1939;12(10):1604-1616.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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