HARRY MANDELBAUM, M.D.
Before the days of blood grouping, hemoglobinuria was a common sequel of blood transfusion, and in many of the cases renal insufficiency developed, usually with lethal termination. Such hemolytic transfusion reactions were first described by Denys1 in 1667. Their frequent occurrence in his cases was not surprising, for he had been injecting sheep's blood into human beings. However, similar reactions occurred in a large percentage of the cases where human blood, exclusively, was transfused. This served as a barrier to the wide usage of blood transfusion as a therapeutic measure.
In 1900 and 1901, Landsteiner2 showed that the serum of
MANDELBAUM H. HEMOLYTIC REACTION FOLLOWING BLOOD TRANSFUSION; REPORT OF A CASE OF INTRA-GROUP INCOMPATIBILITY1. Ann Intern Med. ;12:1699–1708. doi: 10.7326/0003-4819-12-10-1699
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Published: Ann Intern Med. 1939;12(10):1699-1708.
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