TOM D. SPIES, M.D.; WILLIAM B. BEAN, M.D.; WILLIAM F. ASHE, M.D.
In 1735 Gaspar Casal, a Spanish physician, first described pellagra and shrewdly pointed out that this disease is related to an inadequate diet.1 That diet was the controlling factor in the etiology of the disease was not suggested again until the work of Goldberger, Waring and Willets2 in 1915. During the next two decades, the full significance of diet in the development of pellagra gradually became evident because of the frequent association of the disease with faulty nutrition. Later, the administration of a high caloric diet, rich in protein and vitamins, supplemented with large amounts of antipellagric materials such as
SPIES TD, BEAN WB, ASHE WF. RECENT ADVANCES IN THE TREATMENT OF PELLAGRA AND ASSOCIATED DEFICIENCIES1. Ann Intern Med. ;12:1830–1844. doi: 10.7326/0003-4819-12-11-1830
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Published: Ann Intern Med. 1939;12(11):1830-1844.
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