JAMES F. WEIR, M.D., F.A.C.P.
Jaundice is probably the symptom which leads all others in attracting attention to hepatic disease. In its absence, the occurrence of ascites, pruritus, hematemesis, melanoderma, or enlargement of the liver or spleen may indicate the presence of hepatic disease. There are, however, many hepatic conditions not associated with these symptoms and signs and, in such cases, diagnosis must rest largely on suspicion. In the recognition of subclinical cases, a clue is frequently obtained from careful scrutiny of the history and close observation of the patient. In doubtful cases, a review of possible etiologic factors may lead to further search for
WEIR JF. ATROPHY AND NECROSIS OF THE LIVER WITHOUT JAUNDICE1. Ann Intern Med. 1939;12:1845–1854. doi: 10.7326/0003-4819-12-11-1845
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Published: Ann Intern Med. 1939;12(11):1845-1854.
Gastroenterology/Hepatology, Liver Disease.
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