MORRIS H. NATHANSON, M.D., F.A.C.P.
It is well established that epinephrine is the most valuable therapeutic agent in the prevention and treatment of cardiac standstill. More recently the more stable compound, ephedrine, has been used in the treatment of the Adams-Stokes syndrome. The action of this drug in increasing ventricular excitability is variable and at times minimal, so that consistent results are not obtained and many therapeutic failures have been reported. In previous studies on the effect of drugs on the cardiac standstill induced by pressure on the carotid sinus,1 it was found that the standstill could be prevented by a large group of substances
NATHANSON MH. THE ACTION OF PARAHYDROXYPHENYLISOPROPYLAMINE (PAREDRINE) ON THE HEART; A CLINICAL STUDY OF A NEW EPINEPHRINE-LIKE COMPOUND1. Ann Intern Med. ;12:1855–1869. doi: 10.7326/0003-4819-12-11-1855
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Published: Ann Intern Med. 1939;12(11):1855-1869.
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